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Introducing
Boltz-2 is our latest foundation model for understanding biomolecular interactions, achieving state-of-the-art accuracy on structure and binding affinity of small molecule–protein complexes — approaching the performance of FEP in affinity prediction at 1000x the speed
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Mission

Boltz is a family of open source foundation models for molecular biology developed by the Boltz Team at MIT with industry collaborators from Genesis, Recursion and NVIDIA

Try Boltz

Boltz is free and available for academic and commercial use under an MIT license.

Boltz-1

The widely-adopted open-source all atom co-folding model

Boltz-2

Our newest, most powerful model with improved structure and controllability

Boltz-2 Affinity

The world’s best AI affinity prediction model, approaching the accuracy of FEP+ at 1000x the speed

Get in Touch

Developed by the Boltz Team at MIT with support from Recursion and Genesis Therapeutics
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